Lee-Way Jin, MD, PhD - Core Co-Leader
Professor, Pathology and Laboratory Medicine
lwjin@ucdavis.edu
916-703-0392
https://health.ucdavis.edu/team/pathology/21980/lee-way-jin
Dr. Jin is professor of pathology in the School of Medicine, PI and Director of the Neuropathology Core in the NIA-funded UC Davis Alzheimer’s Disease Center (ADC). He will leverage the basic, translational, and clinical scientific resources at his disposal to support the scientific goals in AD and translational synergy of this program project.
K.C. Kent Lloyd, PhD - Core Co-Leader
Professor and Director, Department of Surgery, School of Medicine Mouse Biology Program
kclloyd@ucdavis.edu
916-734-3528
https://biology.ucdavis.edu/people/kc-kent-lloyd
Dr. Lloyd is professor of surgery in the School of Medicine and Director of the UC Davis Mouse Biology Program, a unique campus-wide resource providing research support for most studies involving the development, manipulation, maintenance, and study of transgenic, genetically-altered, and genome edited mutant mice. He also serves as Project Director (PD) for the Knockout Mouse Production and Phenotyping (KOMP2) Project, the Mutant Mouse Regional Resource Center (MMRRC), the Mouse Metabolic Phenotyping Center (MMPC), and the Mouse Biology Shared Resource for the NCI-designated Comprehensive Cancer Center at UC Davis. He has a broad background in mouse biology and genetics, with specific training and expertise in transgenic and knockout production as well as broad-spectrum physiological phenotyping.
Investigators: Izumi Maezawa, Ph.D., Jill L. Silverman, Ph.D.
Consultant: Charles DeCarli, M.D.
Core Summary:
The mouse remains the quintessential model organism for the study of dietary perturbations on the metabolism of aging and cognition. Our projects use complex strategies that include different regimens of diet or different pharmacological treatments, and a large number of aging-related mouse genetic models and mouse models of Alzheimer’s disease. . Investigation of aging in mice requires attention to controlling genetic, environmental, and microbial variables to minimize variation among individuals. In addition, practices in producing, treating, and analyzing the large number of mice used in our projects need to be standardized. Centralized core services are needed to effectively support the research mission and enable scientific synergy. Core C, the Mouse Production, Testing, and Research Support Core, will provide the technical, professional and physical infrastructure to effectively execute an accurate analysis of age-related metabolic phenopathologies in mutant and wildtype mice.
Core Services:
- Breed and provide aged-matched male and female experimental cohorts of mutant and wildtype (control) mouse lines from dedicated rooms in an AALAC-accredited, high-containment barrier vivarium to all relevant research projects.
- Conduct phenotyping methods to characterize mice after various proposed interventions, which include neurobehavioral assessment, blood sample collection, and, following necropsy, neuropathology, neurochemistry, and electrophysiological recording.